Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis

Abstract At advanced phases of atherosclerosis, the rupture and thrombogenesis of vulnerable plaques emerge as primary triggers for acute cardiovascular events and fatalities. Pathogenic infection such as periodontitis-associated Porphyromonas gingivalis (Pg) has been suspected of increasing the ris...

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Bibliographic Details

Published in:	Signal Transduction and Targeted Therapy
Main Authors:	Xiaofei Huang, Mengru Xie, Yixuan Wang, Xiaofeng Lu, Feng Mei, Kaiwen Zhang, Xinlong Yang, Guangjin Chen, Ying Yin, Guangxia Feng, Wencheng Song, Nianguo Dong, Xuliang Deng, Songling Wang, Lili Chen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-05-01
Online Access:	https://doi.org/10.1038/s41392-025-02251-6