Hydrogen sulfide as a therapeutic agent for diabetic wounds: effects on inflammation and fibroblast pyroptosis

IntroductionChronic nonhealing wounds are one of the most serious complications of diabetes mellitus (DM), with limited treatment options. Hydrogen sulfide (H2S) plays a protective role against multiple inflammatory diseases. This study aimed to explore the effects of H2S on diabetic skin wound heal...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Fusheng Zhao, Yuanyuan Li, Qunying Hu, Jiali Xu, Na Zhang, Yonglan Chen, Xinyue Jiang, Chunfu Gu, Kexin Zhang, Geng Wu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	hydrogen sulfide diabetic skin wound healing skin fibroblast NLRP3 inflammasome pyroptosis NF-κB pathway
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558443/full