Systematic Analysis of Whole Exome Sequencing Determines RET G691S Polymorphism as Germline Variant in Melanoma

The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by glial cell derived neutrotrophic factor (GDNF). Previous studies have found that a single nucleotide polymorphism (SNP), RETp (G691S), in the juxtamembrane domain enhances the signaling pathway and promotes tumor growth b...

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書誌詳細

出版年:	Marshall Journal of Medicine
主要な著者:	Brent J. Smith Jr, Jennifer D. Hintzsche, Carol M. Amato, Aik-Choon Tan, Keith R. Wells, Allison J. Applegate, Rita T. Gonzalez, Jodie R. Barr, William A. Robinson
フォーマット:	論文
言語:	英語
出版事項:	Marshall University 2017-04-01
主題:	RETp G691S melanoma whole exome sequencing germline variant
オンライン･アクセス:	https://mds.marshall.edu/cgi/viewcontent.cgi?article=1119&context=mjm