The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing Rivaroxaban in Combination with Polymers

Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB is prepared by changing the drug:polymer...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Pharmaceutics
المؤلفون الرئيسيون: Jong-Hwa Lee, Hyeong Sik Jeong, Jong-Woo Jeong, Tae-Sung Koo, Do-Kyun Kim, Young Ho Cho, Gye Won Lee
التنسيق: مقال
اللغة:الإنجليزية
منشور في: MDPI AG 2021-03-01
الموضوعات:
rivaroxaban (RXB)
amorphous solid dispersion (ASD)
hot-melt extruding technique
quality by design (QbD)
bioavailability
الوصول للمادة أونلاين:https://www.mdpi.com/1999-4923/13/3/344

الانترنت

https://www.mdpi.com/1999-4923/13/3/344

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