Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy

Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling pathway is dysregulated in nearly all kinds of neoplasms, with the component in this pathway alternations. RAF/MEK/ERK signaling cascade...

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Bibliographic Details
Published in:Molecular Biomedicine
Main Authors: Qingfang Li, Zhihui Li, Ting Luo, Huashan Shi
Format: Article
Language:English
Published: Springer 2022-12-01
Subjects:
PI3K/AKT/mTOR
RAF/MEK/ERK
Small molecular inhibitors
Cancer therapy
Combination inhibitor
Online Access:https://doi.org/10.1186/s43556-022-00110-2

Internet

https://doi.org/10.1186/s43556-022-00110-2

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