Basal cell adhesion molecule (BCAM) promotes mesothelial-to-mesenchymal transition and tumor angiogenesis through paracrine signaling

Abstract Background High expression of basal cell adhesion molecule (BCAM) is a hallmark of ovarian cancer (OC) progression. BCAM facilitates transcoelomic dissemination by promoting mesothelial cell clearance at peritoneal attachment sites of tumor cell spheroids. We investigated how BCAM mediates...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Suresh Sivakumar, Sonja Lieber, Raimund Dietze, Vanessa M. Beutgen, Eileen C. Sutor, Sophie Heidemann, Florian Finkernagel, Julia Teply-Szymanski, Andrea Nist, Thorsten Stiewe, Katrin Roth, Silke Reinartz, Johannes Graumann, Sabine Müller-Brüsselbach, Rolf Müller
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Basal cell adhesion molecule (BCAM) Mesothelial-to-mesenchymal transition (MMT) Cancer cell migration Ovarian cancer metastasis Tumor angiogenesis
Online Access:	https://doi.org/10.1186/s12964-025-02128-9