Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis

Abstract Background Influenza A viruses (IAV) are extremely common respiratory viruses for the acute exacerbation of chronic obstructive pulmonary disease (AECOPD), in which IAV infection may further evoke abnormal macrophage polarization, amplify cytokine storms. Melatonin exerts potential effects...

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Bibliographic Details

Published in:	Respiratory Research
Main Authors:	Meng-Meng Xu, Jia-Ying Kang, Qiu-Yan Wang, Xing Zuo, Yuan-Yuan Tan, Yuan-Yuan Wei, Da-Wei Zhang, Ling Zhang, Hui-Mei Wu, Guang-He Fei
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Subjects:	Melatonin Chronic obstructive pulmonary disease Influenza virus Macrophage polarization Apoptosis Interleukin-1β
Online Access:	https://doi.org/10.1186/s12931-024-02815-0