Beneficial Effects of Anti-Interleukin-6 Antibodies on Impaired Gastrointestinal Motility, Inflammation and Increased Colonic Permeability in a Murine Model of Sepsis Are Most Pronounced When Administered in a Preventive Setup.

BACKGROUND AND OBJECTIVES:During sepsis, gastrointestinal ileus, mucosal barrier dysfunction and bacterial translocation are accepted to be important triggers that can maintain or exacerbate the septic state. In the caecal ligation and puncture animal model of sepsis, we demonstrated that systemic a...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Sara Nullens, Michael Staessens, Cédric Peleman, Philip Plaeke, Surbhi Malhotra-Kumar, Sven Francque, Joris G De Man, Benedicte Y De Winter
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Online Access:	http://europepmc.org/articles/PMC4820138?pdf=render