Autocrine Effects of Tumor-Derived Complement

We describe a role for the complement system in enhancing cancer growth. Cancer cells secrete complement proteins that stimulate tumor growth upon activation. Complement promotes tumor growth via a direct autocrine effect that is partially independent of tumor-infiltrating cytotoxic T cells. Activat...

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Bibliographic Details
Published in:Cell Reports
Main Authors: Min Soon Cho, Hernan G. Vasquez, Rajesha Rupaimoole, Sunila Pradeep, Sherry Wu, Behrouz Zand, Hee-Dong Han, Cristian Rodriguez-Aguayo, Justin Bottsford-Miller, Jie Huang, Takahito Miyake, Hyun-Jin Choi, Heather J. Dalton, Cristina Ivan, Keith Baggerly, Gabriel Lopez-Berestein, Anil K. Sood, Vahid Afshar-Kharghan
Format: Article
Language:English
Published: Elsevier 2014-03-01
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714001144

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http://www.sciencedirect.com/science/article/pii/S2211124714001144

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