Incorporation of noncanonical base Z yields modified mRNA with minimal immunogenicity and improved translational capacity in mammalian cells

Summary: Chemically modified mRNAs hold great potential for therapeutic applications in vivo. Currently, the base modification scheme largely preserves the canonical Watson-Crick base pairing, thus missing one mode of mRNA modulation by altering its secondary structure. Here we report the incorporat...

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Bibliographic Details

Published in:	iScience
Main Authors:	Meng Zhang, Nilmani Singh, Mary Elisabeth Ehmann, Lining Zheng, Huimin Zhao
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Subjects:	Biological sciences Biochemistry Medical biochemistry
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223018163