Sorangicin A Is Active against <i>Chlamydia</i> in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment

Current treatment of <i>Chlamydia trachomatis</i> using doxycycline and azithromycin introduces detrimental side effects on the host’s microbiota. As a potential alternative treatment, the myxobacterial natural product sorangicin A (SorA) blocks the bacterial RNA polymerase. In this stud...

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Bibliographic Details

Published in:	Antibiotics
Main Authors:	Simon Graspeuntner, Katharina Koethke, Celeste Scholz, Lea Semmler, Mariia Lupatsii, Laura Kirchhoff, Jennifer Herrmann, Katharina Rox, Kathrin Wittstein, Nadja Käding, Lars C. Hanker, Marc Stadler, Mark Brönstrup, Rolf Müller, Kensuke Shima, Jan Rupp
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Subjects:	sorangicin A antibiotics <i>Chlamydia trachomatis</i> <i>Chlamydia muridarum</i> mouse novel therapeutics
Online Access:	https://www.mdpi.com/2079-6382/12/5/795