Copper-coordination driven brain-targeting nanoassembly for efficient glioblastoma multiforme immunotherapy by cuproptosis-mediated tumor immune microenvironment reprogramming

Abstract Limited drug accumulation and an immunosuppressive microenvironment are the major bottlenecks in the treatment of glioblastoma multiforme (GBM). Herein, we report a copper-coordination driven brain-targeting nanoassembly (TCe6@Cu/TP5 NPs) for site-specific delivery of therapeutic agents and...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Yang Chen, Hailong Tian, Xiaodian Zhang, Edouard C. Nice, Canhua Huang, Haiyuan Zhang, Shaojiang Zheng
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Subjects:	Glioblastoma multiforme Blood–brain barrier Immunotherapy Cuproptosis cGAS-STING pathway
Online Access:	https://doi.org/10.1186/s12951-024-03059-2