Myeloid AMPK signaling restricts fibrosis but is not required for metformin improvements during CDAHFD-induced NASH in mice

Metabolic programming underpins inflammation and liver macrophage activation in the setting of chronic liver disease. Here, we sought to identify the role of an important metabolic regulator, AMP-activated protein kinase (AMPK), specifically within myeloid cells during the progression of non-alcohol...

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Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	Julia R.C. Nunes, Conor O’Dwyer, Peyman Ghorbani, Tyler K.T. Smith, Samarth Chauhan, Victoria Robert-Gostlin, Madison D. Girouard, Benoit Viollet, Marc Foretz, Morgan D. Fullerton
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	non-alcoholic steatohepatitis NASH AMPK macrophage liver immunometabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227524000695