Gene count normalization in single-cell imaging-based spatially resolved transcriptomics

Abstract Background Recent advances in imaging-based spatially resolved transcriptomics (im-SRT) technologies now enable high-throughput profiling of targeted genes and their locations in fixed tissues. Normalization of gene expression data is often needed to account for technical factors that may c...

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Bibliographic Details
Published in:Genome Biology
Main Authors: Lyla Atta, Kalen Clifton, Manjari Anant, Gohta Aihara, Jean Fan
Format: Article
Language:English
Published: BMC 2024-06-01
Subjects:
Normalization
Scaling factor
Spatial transcriptomics
Differential expression
Online Access:https://doi.org/10.1186/s13059-024-03303-w

Internet

https://doi.org/10.1186/s13059-024-03303-w

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