Use of Microfluidic Capillary Electrophoresis for the Determination of Multi-Component Protein Adsorption Isotherms: Application to High-Throughput Analysis for Hydrophobic Interaction Chromatography

Chromatography is a widely used separation process for purification of biopharmaceuticals that is able to obtain high purities and concentrations. The phenomena that occur during separation, mass transfer and adsorption are quite complex. To better understand these phenomena and their mechanisms, mu...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Elena Lietta, Alessandro Pieri, Elisa Innocenti, Roberto Pisano, Marco Vanni, Antonello A. Barresi
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Subjects:	high-throughput chromatography capillary electrophoresis multi-component adsorption isotherms hydrophobic interaction chromatography
Online Access:	https://www.mdpi.com/1999-4923/13/12/2135