Stoichiometry for entry and binding properties of the Env protein of R5 T cell-tropic HIV-1 and its evolutionary variant of macrophage-tropic HIV-1

ABSTRACTHuman immunodeficiency virus type 1 typically requires a high density of CD4 for efficient entry as a mechanism to target CD4+ T cells (T-tropic), with CCR5 being used most often as the coreceptor. When target T cells are limiting, the virus can evolve to infect cells with a low density of C...

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Bibliographic Details

Published in:	mBio
Main Authors:	Xavier Bonner, Amy Sondgeroth, Amelia McCue, Nathan Nicely, Ashutosh Tripathy, Ean Spielvogel, Matthew Moeser, Ruian Ke, Karin Leiderman, Sarah B. Joseph, Ronald Swanstrom
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-04-01
Subjects:	human immunodeficiency virus virus entry CD4 macrophage tropism receptor stoichiometry
Online Access:	https://journals.asm.org/doi/10.1128/mbio.00321-24