PLGA-microspheres carried circ_0003251 alleviate intervertebral disc degeneration via the miR-637/AKT1 axis

Abstract Background Circular RNA (circRNA) plays a pivotal role in regulating nucleus pulposus cells (NPCs) function, making it a promising therapeutic target for intervertebral disc degeneration (IDD). This study aimed to identify circRNA closely associated with IDD and assess their potential as th...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Shouliang Xiong, Quanlai Zhao, Yu Zhang, Yifeng Li, Xiaoming Yang, Liang Xiao
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Intervertebral disc degeneration Nucleus pulposus cells Circ_0003251 Microspheres
Online Access:	https://doi.org/10.1186/s12967-025-06800-z