Simulating combined monoaminergic depletions in a PD animal model through a bio-constrained differential equations system

IntroductionHistorically, Parkinson's Disease (PD) research has focused on the dysfunction of dopamine-producing cells in the substantia nigra pars compacta, which is linked to motor regulation in the basal ganglia. Therapies have mainly aimed at restoring dopamine (DA) levels, showing effectiv...

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Bibliographic Details

Published in:	Frontiers in Computational Neuroscience
Main Authors:	Samuele Carli, Luigi Brugnano, Daniele Caligiore
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-08-01
Subjects:	Parkinson's disease treatment serotonin noradrenaline computational model network neuroscience
Online Access:	https://www.frontiersin.org/articles/10.3389/fncom.2024.1386841/full