Silibinin inhibits PM2.5-induced liver triglyceride accumulation through enhancing the function of mitochondrial Complexes I and II

BackgroundThe standardized extract of milk thistle seeds, known as silibinin, has been utilized in herbal medicine for over two centuries, with the aim of safeguarding the liver against the deleterious effects of various toxic substances. However, the role of silibinin in Particulate Matter (PM2.5)-...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Dexin Li, Jingxin Zhang, Yuxin Jin, Yaoxuan Zhu, Xiaoqing Lu, Xinmei Huo, Chunshui Pan, Lijun Zhong, Kai Sun, Li Yan, Lulu Yan, Ping Huang, Quan Li, Jing-Yan Han, Yin Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	silibinin lipid accumulation PM2.5 mitochondrial dysfunction oxidative stress
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1435230/full