TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis

Meiotic progression requires coordinated assembly and disassembly of protein complexes involved in chromosome synapsis and meiotic recombination. Mouse TRIP13 and its ortholog Pch2 are instrumental in remodeling HORMA domain proteins. HORMAD proteins are associated with unsynapsed chromosome axes bu...

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Bibliographic Details

Published in:	eLife
Main Authors:	Jessica Y Chotiner, N Adrian Leu, Fang Yang, Isabella G Cossu, Yongjuan Guan, Huijuan Lin, P Jeremy Wang
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-08-01
Subjects:	TRIP13 meiosis spermatogenesis fertility
Online Access:	https://elifesciences.org/articles/92195