A practical guide to simulation for an adaptive trial design with a single interim analysis

Abstract Background The demand for adaptive trial designs is growing because of their flexibility and the potential for efficiency gains over traditional fixed designs. Adaptive trials allow planned modifications to the design based on accumulating data. Simulation is imperative in designing adaptiv...

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Bibliographic Details
Published in:Trials
Main Authors: Kaushala S. Jayawardana, Michael Dymock, Robert K. Mahar, Julie A. Marsh, Katherine J. Lee
Format: Article
Language:English
Published: BMC 2025-10-01
Subjects:
Adaptive trials
Trial design
Simulation
Sample size
Online Access:https://doi.org/10.1186/s13063-025-09100-5

Internet

https://doi.org/10.1186/s13063-025-09100-5

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