TET1: The epigenetic architect of clinical disease progression

The ten-eleven translocation 1 (TET1) protein, a member of the human α-ketoglutarate-dependent dioxygenase TET family, functions as a 5-methylcytosine hydroxylase with a strong affinity for genomic regions enriched with 5′-CpG-3′ dinucleotides, particularly CpG islands. TET1 is critical in initiatin...

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Bibliographic Details

Published in:	Genes and Diseases
Main Authors:	Keyvan Jabbari, Ali Khalafizadeh, Mahboubeh Sheikhbahaei, Hossein Soltaninejad, Sadegh Babashah
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2025-09-01
Subjects:	Clinical diseases DNA demethylation Epigenetics TET1 Therapeutic target
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352304225000029