Silencing of NRF2 Reduces the Expression of ALDH1A1 and ALDH3A1 and Sensitizes to 5-FU in Pancreatic Cancer Cells

Pancreatic cancer remains an intractable cancer with a poor five-year survival rate, which requires new therapeutic modalities based on the biology of pancreatic oncogenesis. Nuclear factor E2 related factor-2 (NRF2), a key cytoprotective nuclear transcription factor, regulates antioxidant productio...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Hong-Quan Duong, Kyu Sic You, Seunghoon Oh, Sahng-June Kwak, Yeon-Sun Seong
Format:	Article
Language:	English
Published:	MDPI AG 2017-07-01
Subjects:	pancreatic cancer NRF2 ALDH1A1 ALDH3A1 5-FU
Online Access:	https://www.mdpi.com/2076-3921/6/3/52