Differential Targeting of Hsp70 Heat Shock Proteins HSPA6 and HSPA1A with Components of a Protein Disaggregation/Refolding Machine in Differentiated Human Neuronal Cells following Thermal Stress

Heat shock proteins (Hsps) co-operate in multi-protein machines that counter protein misfolding and aggregation and involve DNAJ (Hsp40), HSPA (Hsp70), and HSPH (Hsp105α). The HSPA family is a multigene family composed of inducible and constitutively expressed members. Inducible HSPA6 (Hsp70B')...

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Published in:	Frontiers in Neuroscience
Main Authors:	Ian R. Brown, Catherine A. S. Deane
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-04-01
Subjects:	HSPA1A (Hsp70-1) HSPA6 (Hsp70B') HSPA8 (Hsc70) DNAJ (Hsp40) HSPH1 (Hsp105α) human neuronal SH-SY5Y cells
Online Access:	http://journal.frontiersin.org/article/10.3389/fnins.2017.00227/full