The role of NAD-dependent deacetylase sirtuin-2 in liver metabolic stress through regulating pyruvate kinase M2 ubiquitination

Abstract NAD-dependent deacetylase Sirt2 is involved in mammalian metabolic activities, matching energy demand with energy production and expenditure, and is relevant to a variety of metabolic diseases. Here, we constructed Sirt2 knockout and adeno-associated virus overexpression mice and found that...

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Bibliographic Details
Published in:Journal of Translational Medicine
Main Authors: Jingru Guo, Junshu Nie, Dongni Li, Huaixiu Zhang, Tianrui Zhao, Shoufeng Zhang, Li Ma, Jingjing Lu, Hong Ji, Shize Li, Sha Tao, Bin Xu
Format: Article
Language:English
Published: BMC 2024-07-01
Subjects:
Sirt2
Acetylation
PKM2
Glycolysis
Metabolism
Online Access:https://doi.org/10.1186/s12967-024-05435-w

Internet

https://doi.org/10.1186/s12967-024-05435-w

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