Analysis of the effect of hypusination in myeloid cells on colitis and colitis-associated cancer

Hypusine is an amino acid synthesized by the enzyme deoxyhypusine synthase (DHPS). It is critical for the activity of eukaryotic translation initiation factor 5A (EIF5A). We reported that hypusination i) in macrophages supports the innate response towards pathogenic bacteria and ii) in epithelial ce...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Alain P. Gobert, Jordan Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Caroline V. Hawkins, Kamery J. Williams, Alberto G. Delagado, Raghavendra G. Mirmira, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, Keith T. Wilson
Format:	Article
Language:	English
Published:	Elsevier 2024-07-01
Subjects:	Inflammatory bowel diseases Inflammation Hypusine Colon Colorectal cancer Gut microbiota
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844024098694