Design and Synthesis of C-19 Isosteviol Derivatives as Potent and Highly Selective Antiproliferative Agents

Six series of novel isosteviol derivatives; modified in the C-19 position; were synthesized; and their antiproliferative activity was evaluated against three human cancer cell lines (HCT-116; BEL-7402; HepG2) and the human L02 normal cell line in vitro. Most of the derivatives tested here exhibited...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Tian Luan, Li-Hua Cao, Hao Deng, Qing-Kun Shen, Yu-Shun Tian, Zhe-Shan Quan
Format:	Article
Language:	English
Published:	MDPI AG 2018-12-01
Subjects:	isosteviol derivatives antiproliferation HCT-116
Online Access:	http://www.mdpi.com/1420-3049/24/1/121