Inflammatory responses revealed through HIV infection of microglia-containing cerebral organoids

Abstract Cerebral organoids (COs) are valuable tools for studying the intricate interplay between glial cells and neurons in brain development and disease, including HIV-associated neuroinflammation. We developed a novel approach to generate microglia containing COs (CO-iMs) by co-culturing hematopo...

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Bibliographic Details
Published in:Journal of Neuroinflammation
Main Authors: Srinivas D. Narasipura, Janet P. Zayas, Michelle K. Ash, Anjelica F. Reyes, Tanner Shull, Stephanie Gambut, James L. A. Szczerkowski, Charia McKee, Jeffrey R. Schneider, Ramon Lorenzo-Redondo, Lena Al-Harthi, João I. Mamede
Format: Article
Language:English
Published: BMC 2025-02-01
Subjects:
Cerebral organoids
Microglia
HIV
Neuropathogenesis
Neuroinflammation
IPSC
Online Access:https://doi.org/10.1186/s12974-025-03353-2

Internet

https://doi.org/10.1186/s12974-025-03353-2

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