Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.

The activation of conventional T cells upon T cell receptor stimulation critically depends on protein kinase C theta (PKCθ). However, its role in regulatory T (Treg) cell function has yet to be fully elucidated. Using siRNA or the potent and PKC family-selective pharmacological inhibitor AEB071, we...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Kerstin Siegmund, Nikolaus Thuille, Katarzyna Wachowicz, Natascha Hermann-Kleiter, Gottfried Baier
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0175463&type=printable