Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program

Objective: The endoplasmic reticulum (ER)-resident E3 ligase HRD1 and its co-activator Sel1L are major components of ER-associated degradation (ERAD) machinery. Here, we investigated the molecular mechanism and functional significance underlying the circadian regulation of HRD1/Sel1L-mediated protei...

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書誌詳細

出版年:	Molecular Metabolism
主要な著者:	Hyunbae Kim, Juncheng Wei, Zhenfeng Song, Emilio Mottillo, Lobelia Samavati, Ren Zhang, Li Li, Xuequn Chen, Bhanu P. Jena, Jiandie D. Lin, Deyu Fang, Kezhong Zhang
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2021-07-01
主題:	Endoplasmic reticulum ER-associated degradation Lipid metabolism Circadian metabolism Transcriptional regulation
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2212877821000326