Comparative efficacy of five approved Janus kinase inhibitors as monotherapy and combination therapy in patients with moderate-to-severe active rheumatoid arthritis: a systematic review and network meta-analysis of randomized controlled trials

BackgroundThe European League of Rheumatology(EULAR)guidelines recommend Janus kinase (JAK) inhibitors for patients with moderate to severe rheumatoid arthritis (RA) who are insensitive or under-responsive to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). But there was no...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Wenting Cai, Rui Tong, Yue Sun, Yao Yao, Jinping Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Subjects:	Janus kinase inhibitors conventional synthetic disease-modifying anti-rheumatic drugs network meta-analysis rheumatoid arthritis efficacy safety
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1387585/full