Ablation of progranulin augments microglial activation and accelerates prion progression

Abstract Mutations or polymorphisms in GRN, encoding the CNS glycoprotein progranulin (PGRN), have been linked to several neurodegenerative diseases. In this study, we explored the role of PGRN in prion diseases. We observed that prion infection upregulated microglial PGRN expression. Following intr...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Bei Li, Yiyue Shi, Wenyu Hou, Haoyuan Guan, Jun Li, Tuo Yi, Wei Li, Donglin Cai, Petra Schwarz, Adriano Aguzzi, Caihong Zhu
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	Progranulin Prion disease Microglia Neuroinflammation Neurodegeneration
Online Access:	https://doi.org/10.1186/s40478-025-02128-3