Crocin's role in modulating MMP2/TIMP1 and mitigating hypoxia-induced pulmonary hypertension in mice

Abstract To explore the molecular pathogenesis of pulmonary arterial hypertension (PAH) and identify potential therapeutic targets, we performed transcriptome sequencing of lung tissue from mice with hypoxia-induced pulmonary hypertension. Our Gene Ontology analysis revealed that “extracellular matr...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Jing Deng, Rui-Qi Wei, Wen-Mei Zhang, Chang-Yu Shi, Rui Yang, Ming Jin, Chunmei Piao
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Subjects:	Pulmonary hypertension Transcriptome sequencing Matrix metalloproteinase Matrix metalloproteinase tissue inhibitor Pulmonary arterial fibroblast Crocin
Online Access:	https://doi.org/10.1038/s41598-024-62900-8