Coronary cytoskeletal modulation of coronary blood flow in the presence and absence of type 2 diabetes: the role of cofilin

BackgroundCoronary resistance microvessels (CRMs) from type 2 diabetic (T2DM) mice and pigs are less stiff compared to normal, a finding that is dictated by less stiff coronary vascular smooth muscle cells (VSMCs). Cofilin is an endogenous actin regulatory protein that depolymerizes filamentous (F)-...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Patricia E. McCallinhart, Kathlyene R. Stone, Pamela A. Lucchesi, Aaron J. Trask
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	coronary microcirculation vascular smooth muscle cells diabetes cofilin actin remodeling coronary blood flow
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2025.1561867/full