Population Pharmacokinetics and Dosing Optimization of Piperacillin-Tazobactam in Critically Ill Patients on Extracorporeal Membrane Oxygenation and the Influence of Concomitant Renal Replacement Therapy

ABSTRACT Critical illness and extracorporeal circulation, such as extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT), may alter the pharmacokinetics of piperacillin-tazobactam. We aimed to develop a population pharmacokinetic model of piperacillin-tazobactam i...

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出版年:	Microbiology Spectrum
主要な著者:	Jongsung Hahn, Kyoung Lok Min, Soyoung Kang, Seungwon Yang, Min Soo Park, Jin Wi, Min Jung Chang
フォーマット:	論文
言語:	英語
出版事項:	American Society for Microbiology 2021-12-01
主題:	PTA continuous renal replacement therapy creatinine clearance extracorporeal membrane oxygenation pharmacodynamics pharmacokinetics
オンライン･アクセス:	https://journals.asm.org/doi/10.1128/Spectrum.00633-21