Synthesis and Bioevaluation of New Stable Derivatives of Chrysin-8-<i>C</i>-Glucoside That Modulate the Antioxidant Keap1/Nrf2/HO-1 Pathway in Human Macrophages

<b>Background/Objectives</b>: The beneficial effects of the flavonoid chrysin can be reduced by its poor oral bioavailability. It has been shown that chrysin-8-C-glucoside (<b>1</b>) has a better absorption capability. The aim of this study was to evaluate the antioxidant and...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Javier Ávila-Román, Lirenny Quevedo-Tinoco, Antonio J. Oliveros-Ortiz, Sara García-Gil, Gabriela Rodríguez-García, Virginia Motilva, Mario A. Gómez-Hurtado, Elena Talero
Format:	Article
Language:	English
Published:	MDPI AG 2024-10-01
Subjects:	chrysin-8-<i>C</i>-glucoside derivatives Nrf2 HO-1 docking Keap1 dexamethasone
Online Access:	https://www.mdpi.com/1424-8247/17/10/1388