Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

Mutations in Proprotein Convertase Subtilisin Kexin 9 (PCSK9) have been associated with autosomal dominant hypercholesterolemia. In vivo kinetic studies indicate that LDL catabolism was impaired and apolipoprotein B (apoB)-containing lipoprotein synthesis was enhanced in two patients presenting with...

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Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	Florent Lalanne, Gilles Lambert, Marcelo J.A. Amar, Maud Chétiveaux, Yassine Zaïr, Anne-Laure Jarnoux, Khadija Ouguerram, José Friburg, Nabil G. Seidah, H. Bryan Brewer, Jr., Michel Krempf, Philippe Costet
Format:	Article
Language:	English
Published:	Elsevier 2005-06-01
Subjects:	Proprotein Convertase Subtilisin Kexin 9 low density lipoprotein apolipoprotein B
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520330364