Less is more: We are administering too much protamine in cardiac surgery

Context: Protamine is routinely administered to neutralize the anticlotting effects of heparin, traditionally at a dose of 1 mg for every 100 IU of heparin—a 1:1 ratio protamine sparing effects—but this is based more on experience and practice than literature evidence. The use of Hemostasis Manageme...

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Bibliographic Details
Published in:Annals of Cardiac Anaesthesia
Main Authors: Francesco De Simone, Pasquale Nardelli, Margherita Licheri, Giovanna Frau, Martina Baiardo Redaelli, Fabrizio Monaco, Alberto Zangrillo, Giovanni Landoni
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Subjects:
anesthesia
cardiac surgery
cardiopulmonary bypass
heparin
hemostasis management system
intensive care
protamine
Online Access:http://www.annals.in/article.asp?issn=0971-9784;year=2021;volume=24;issue=2;spage=178;epage=182;aulast=Simone

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http://www.annals.in/article.asp?issn=0971-9784;year=2021;volume=24;issue=2;spage=178;epage=182;aulast=Simone

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