Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice.

<label>OBJECTIVE</label>The gene encoding the methionine salvage pathway methylthioadenosine phosphorylase (MTAP) is a tumor suppressor gene that is frequently inactivated in a wide variety of human cancers. In this study, we have examined if heterozygosity for a null mutation in Mtap (M...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Yuwaraj Kadariya, Baiqing Tang, Liqun Wang, Tahseen Al-Saleem, Kyoko Hayakawa, Michael J Slifker, Warren D Kruger
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	http://europepmc.org/articles/PMC3694069?pdf=render