Multi-targeted therapy resistance via drug-induced secretome fucosylation

Cancer secretome is a reservoir for aberrant glycosylation. How therapies alter this post- translational cancer hallmark and the consequences thereof remain elusive. Here, we show that an elevated secretome fucosylation is a pan-cancer signature of both response and resistance to multiple targeted t...

Full description

Bibliographic Details

Published in:	eLife
Main Authors:	Mark Borris D Aldonza, Junghwa Cha, Insung Yong, Jayoung Ku, Pavel Sinitcyn, Dabin Lee, Ryeong-Eun Cho, Roben D Delos Reyes, Dongwook Kim, Soyeon Kim, Minjeong Kang, Yongsuk Ku, Geonho Park, Hye-Jin Sung, Han Suk Ryu, Sukki Cho, Tae Min Kim, Pilnam Kim, Je-Yoel Cho, Yoosik Kim
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2023-03-01
Subjects:	fucosylation n-linked glycosylation targeted therapy secretome drug resistance cancer
Online Access:	https://elifesciences.org/articles/75191