IL-17-Dependent Dysregulated Cutaneous Immune Homeostasis in the Absence of the Wiskott–Aldrich Syndrome Protein

Wiskott–Aldrich Syndrome (WAS) is characterized by recurrent infections, thrombocytopenia, and eczema. Here, we show that WASp-deficient mice on a BALB/c background have dysregulated cutaneous immune homeostasis with increased leukocyte accumulation in the skin, 1 week after birth. Increased cutaneo...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Katherine E. Herman, Takeshi Yoshida, Angela Hughson, Alex Grier, Steven R. Gill, Lisa A. Beck, Deborah J. Fowell
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-02-01
Subjects:	Wiskott–Aldrich syndrome skin immune homeostasis IL-17 inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.817427/full