IL-17-Dependent Dysregulated Cutaneous Immune Homeostasis in the Absence of the Wiskott–Aldrich Syndrome Protein

Wiskott–Aldrich Syndrome (WAS) is characterized by recurrent infections, thrombocytopenia, and eczema. Here, we show that WASp-deficient mice on a BALB/c background have dysregulated cutaneous immune homeostasis with increased leukocyte accumulation in the skin, 1 week after birth. Increased cutaneo...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	Katherine E. Herman, Takeshi Yoshida, Angela Hughson, Alex Grier, Steven R. Gill, Lisa A. Beck, Deborah J. Fowell
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-02-01
Subjects:	Wiskott–Aldrich syndrome skin immune homeostasis IL-17 inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.817427/full

Similar Items

Diffuse Large B-Cell Lymphoma Associated with Wiskott-Aldrich Syndrome: A Case Report
by: Golsa Shekarkhar, et al.
Published: (2025-09-01)

Fatal Cytomegalovirus Gastrointestinal Disease in an Infant with Wiskott-Aldrich Syndrome
by: Kuan-Ying Huang, et al.
Published: (2008-01-01)

Confirmed diagnosis of classic Wiskott–Aldrich syndrome in East Africa: a case report
by: Mpokigwa Kiputa, et al.
Published: (2022-07-01)

A Novel Mutation in a Patient with Wiskott-Aldrich Syndrome
by: Yurday Öncül, et al.
Published: (2020-05-01)

Detection of Six Novel Mutations in WASP Gene in Fifteen Iranian Wiskott-Aldrich Patients
by: Sepideh Safaei, et al.
Published: (2012-12-01)

A case of Wiskott — Aldrich syndrome in an infant
by: E. V. Churyukina, et al.
Published: (2023-10-01)

Wiskott-Aldrich Syndrome. A Report of a New Mutation
by: Nelva Lizbeth Guillén-Rocha, et al.
Published: (2014-06-01)

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector
by: Swati Singh, et al.
Published: (2017-03-01)

A Novel Mutation in a Child with Atypical Wiskott-Aldrich Syndrome Complicated by Cytomegalovirus Infection
by: Zühre Kaya, et al.
Published: (2019-02-01)

Wiskott-Aldrich syndrome mutation in two Turkish siblings with X-linked thrombocytopenia
by: Göksel Leblebisatan, et al.
Published: (2011-05-01)

Wiskott-Aldrich syndrome mutation in two Turkish siblings with X-linked thrombocytopenia
by: Göksel Leblebisatan, et al.
Published: (2011-06-01)

Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells
by: Elizabeth Rivers, et al.
Published: (2020-11-01)

When Immunodeficiency Meets Neurosurgery: Brain Abscess in a Wiskott-Aldrich Syndrome Patient
by: Jayasooriya HK, et al.
Published: (2025-01-01)

CASE REPORT: FAMILIAL WISKOTT-ALDRICH SYNDROME
by: Belykh Natalia Anatolievna, et al.
Published: (2024-12-01)

Wiskott–Aldrich syndrome in a child presenting with macrothrombocytopenia
by: Jose Maria Bastida, et al.
Published: (2017-05-01)

Clinical Features and Outcomes of 23 Patients with Wiskott- Aldrich Syndrome: A Single-Center Experience
by: Şule Haskoloğlu, et al.
Published: (2020-11-01)

X-linked Thrombocytopenia with Normal Wiskott-Aldrich Syndrome Protein Expression in Lymphocytes and a Novel Wiskott-Aldrich Syndrome Protein Gene Variant: A Case Report and Brief Review of the Literature
by: Serena Hamanaka, MD, et al.
Published: (2024-12-01)

Gene editing-based targeted integration for correction of Wiskott-Aldrich syndrome
by: Melissa Pille, et al.
Published: (2024-03-01)

New insights into Wiskott-Aldrich syndrome: ten novel WAS mutations and their clinical impact in a Brazilian cohort
by: Lucas W. Santos, et al.
Published: (2025-07-01)

Allogeneic hematopoietic stem cell transplantation outcome in oldest known surviving patients with Wiskott-Aldrich syndrome
by: Ariharan Anantharachagan, MBChB, MRCP, MsC,FRCPath, et al.
Published: (2024-02-01)

Signal integration during T lymphocyte activation and function: lessons from the Wiskott-Aldrich syndrome
by: Vinícius eCotta-de-Almeida, et al.
Published: (2015-02-01)

Assessment of immature platelet fraction in the diagnosis of Wiskott-Aldrich syndrome
by: Robert eSokolic, et al.
Published: (2015-06-01)

Wiskott-Aldrich Syndrome; An X-Linked Primary Immunodeficiency Disease with Unique and Characteristic Features
by: Tadashi Ariga
Published: (2012-01-01)

Characterization of a WAS splice-site variant in a patient with Wiskott-Aldrich syndrome
by: Elisabetta Toriello, et al.
Published: (2025-01-01)

Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and Progression
by: Xin XIE, Yan CHEN, Zhixu HE, Pei HUANG, Qinghua CHEN
Published: (2022-05-01)

Síndrome de Wiskott-Aldrich asociado a absceso de la glándula tiroides. Informe de caso
by: Gladys Iglesias Díaz, et al.
Published: (2020-12-01)

The Misleading Normal in an Unusual Case of Wiskott–Aldrich Syndrome: A Case Report with Review of Literature
by: Vanya Rai, et al.

The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation
by: Melissa Pille, et al.
Published: (2023-06-01)

Case Report: Wiskott-Aldrich Syndrome Caused by Extremely Skewed X-Chromosome Inactivation in a Chinese Girl
by: Xuening Hou, et al.
Published: (2021-07-01)

A novel splice site mutation in WAS gene in patient with Wiskott-Aldrich syndrome and chronic colitis: a case report
by: Hossein Esmaeilzadeh, et al.
Published: (2018-07-01)

Report of clinical presentations and two novel mutations in patients with Wiskott-Aldrich syndrome/X-linked Thrombocytopenia
by: Natsumon Udomkittivorakul, et al.
Published: (2022-07-01)

Síndrome de Wiskott-Aldrich con plaquetas de tamaño normal y mutación c.295C>T en el gen WAS. Informe de caso
by: Maria Luiza Cunha-Carneiro, et al.
Published: (2023-04-01)

Haploidentical stem cell transplantation with posttransplant cyclophosphamide in children with Wiskott–Aldrich syndrome: a case report
by: Le Nguyen Ngoc Quynh, et al.
Published: (2025-02-01)

CRISPR/Cas9-mediated deletion of the Wiskott-Aldrich syndrome locus causes actin cytoskeleton disorganization in murine erythroleukemia cells
by: Vanessa Fernández-Calleja, et al.
Published: (2019-01-01)

Off Label Use of Eltrombopag and Recombinant Activated Factor VII in Wiskott-Aldrich Syndrome. A Case Report and Review of Literature
by: Alkistis Adramerina, et al.
Published: (2022-04-01)

Sinonasal diffuse large B-cell lymphoma in a patient with Wiskott–Aldrich syndrome: A case report and literature review
by: Xiwen Sun, et al.
Published: (2023-01-01)

Myelin oligodendrocyte glycoprotein antibody-associated disease as a novel presentation of central nervous system autoimmunity in a pediatric patient with Wiskott-Aldrich syndrome
by: Vivien X. Xie, et al.
Published: (2023-08-01)

Efficacy of rituximab for the treatment and prevention of autoimmunity in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia
by: Saori Katayama, et al.
Published: (2024-06-01)

When WAS Gene Diagnosis Is Needed: Seeking Clues Through Comparison Between Patients With Wiskott-Aldrich Syndrome and Idiopathic Thrombocytopenic Purpura
by: Ying-Ying Jin, et al.
Published: (2019-07-01)

The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse
by: Raïssa Houmadi, et al.
Published: (2018-01-01)