The structural basis for synergistic inhibition of geranylgeranyl diphosphate synthase with stereoisomeric triazole bisphosphonates
Several incurable cancers are characterized by abnormal protein production and secretion. A prime example being multiple myeloma and its excessive production of non-functional antibodies (M protein). Proper secretion of M protein is necessary for cancer cell survival but is mediated by intracellular...
| 發表在: | Structural Dynamics |
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| Main Authors: | , , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
AIP Publishing LLC and ACA
2025-10-01
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| 在線閱讀: | https://pubs.aip.org/aca/sdy/article-pdf/12/5_Supplement/A386/20775141/a386_1_4.0001175.pdf |