The structural basis for synergistic inhibition of geranylgeranyl diphosphate synthase with stereoisomeric triazole bisphosphonates

Several incurable cancers are characterized by abnormal protein production and secretion. A prime example being multiple myeloma and its excessive production of non-functional antibodies (M protein). Proper secretion of M protein is necessary for cancer cell survival but is mediated by intracellular...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Structural Dynamics
المؤلفون الرئيسيون: Andrew Pham, Sarah Holstein, Gloria Borgstahl
التنسيق: مقال
اللغة:الإنجليزية
منشور في: AIP Publishing LLC and ACA 2025-10-01
الوصول للمادة أونلاين:https://pubs.aip.org/aca/sdy/article-pdf/12/5_Supplement/A386/20775141/a386_1_4.0001175.pdf

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