MDK promotes M2 macrophage polarization to remodel the tumour microenvironment in clear cell renal cell carcinoma

Abstract The efficacy of immunotherapy for clear cell renal cell carcinoma (ccRCC), especially advanced ccRCC, is limited, presenting a clinical challenge. This limitation is closely tied to the immune regulation network. Understanding the heterogeneity of the tumour microenvironment (TME) is crucia...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Naipeng Shi, Saisai Chen, Dong Wang, Tiange Wu, Nieke Zhang, Ming Chen, Xuefei Ding
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Subjects:
ccRCC
Tumour microenvironment
M2 macrophage
MDK
Immunosuppression
Online Access:https://doi.org/10.1038/s41598-024-69183-z

Internet

https://doi.org/10.1038/s41598-024-69183-z

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