Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease

Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD). A previous study showed Activin A, whose transcription is upregulated by calcium influx via synaptic NMDARs, su...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Wissam B. Nassrallah, Daniel Ramandi, Judy Cheng, Jean Oh, James Mackay, Marja D. Sepers, David Lau, Hilmar Bading, Lynn A. Raymond
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Subjects:	Striatal medium-sized spiny neuron Synapse Patch clamp recording Glutamatergic neurotransmission
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996123003765