IRF7-deficient MDBK cell based on CRISPR/Cas9 technology for enhancing IBRV replication

Infectious bovine rhinotracheitis (IBR), characterized by acute respiratory lesions in cattle, is a major infectious disease caused by bovine alphaherpesvirus-1 (BoAHV-1). Control of this disease is primarily depending on vaccination. Madin-Darby bovine kidney cells (MDBK) being the main host cells...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Guiyang Ge, Dongli Li, Qian Ling, Lihui Xu, Emad Beshir Ata, Xiaolin Wang, Keyan Li, Wen Hao, Qinglong Gong, Jianming Li, Kun Shi, Xue Leng, Rui Du
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Subjects:	CRISPR/Cas9 gene knockout IRF7 IBRV viral replication
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2024.1483527/full