Prophylaxis of Gout Flares in Patients with Renal Impairment: Dosing Adjustments with Colchicine Oral Solution Informed by a Pharmacokinetic Model

Abstract Introduction Patients receiving the standard prophylaxis dose of colchicine for gout flares are at increased risk for developing toxicity if there are pre-existing renal impairment or drug–drug interactions. Guidelines recommend exercising caution, deferring dose adjustment to the clinician...

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Bibliographic Details

Published in:	Rheumatology and Therapy
Main Authors:	Jaymin Shah, Michael H. Pillinger, Elaine K. Chan, Dmitri Lissin
Format:	Article
Language:	English
Published:	Adis, Springer Healthcare 2025-06-01
Subjects:	Colchicine Glomerular filtration rate Gout Narrow therapeutic index Oral solution Renal impairment
Online Access:	https://doi.org/10.1007/s40744-025-00772-8