Provoking tumor disulfidptosis by single-atom nanozyme via regulating cellular energy supply and reducing power

Abstract Disulfidptosis, a recently identified form of programmed cell death, is initiated by depletion of endogenous nicotinamide adenine dinucleotide phosphate (NADPH) under glucose starvation. Tumor cells, owing to their heightened requirements of energy and nutrients, are more susceptible to dis...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Wenxin Yu, Duo Jin, Yajie Zhang, Shenghu Wang, Jiaji Yu, Manman Liu, Yi Dai, Yichen Yin, Junjie Cheng, Yangzhong Liu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Online Access:	https://doi.org/10.1038/s41467-025-60015-w