Nuclear localization of human MEIOB requires its NLS in the OB domain and interaction with SPATA22

MEIOB is a vital protein in meiotic homologous recombination and plays an indispensable role in human gametogenesis. In mammals, MEIOB and its partner SPATA22 form a heterodimer, ensuring their effective localization on single-strand DNA (ssDNA) and proper synapsis processes. Mutations in human MEIO...

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Bibliographic Details

Published in:	Acta Biochimica et Biophysica Sinica
Main Authors:	Xu Yating, Chen Zhen, Wu Panfeng, Qu Wei, Shi Hanqing, Cheng Muyang, Xu Yumin, Jin Tingyu, Liu Cong, Li Yi, Luo Mengcheng
Format:	Article
Language:	English
Published:	China Science Publishing & Media Ltd. 2022-11-01
Subjects:	MEIOB SPATA22 NLS OB domain protein interaction
Online Access:	https://www.sciengine.com/doi/10.3724/abbs.2022156